ABSTRACT
Background
Current automated cervical cytology screening systems require purchase of a dedicated preparation machine and use of a specific staining protocol. CytoProcessor® (DATEXIM, Caen, France) is a new automated system, designed to integrate seamlessly into the laboratory’s existing workflow. We previously demonstrated the superior performance of CytoProcessor® for diagnosis of ThinPrep slides compared to the ThinPrep Imaging System (HOLOGIC, Marlborough, MA). Next, we analyzed whether CytoProcessor® technology can be adapted for use on Novaprep slides.
Methods
Using artificial intelligence, we developed a new algorithm in CytoProcessor® for the analysis of slides prepared using the NOVAPREP Processor System NPS50 (Novacyt, Vélizy‐Villacoublay, France). A representative population of 309 cases was selected from the routine workflow in a public hospital. We compared the diagnoses made using CytoProcessor® or conventional screening with a microscope. All discordances were resolved by a consensus committee.
Results
The performance of CytoProcessor® in terms of diagnostic accuracy on Novaprep slides was very similar to that observed previously on ThinPrep slides. Compared to conventional screening, CytoProcessor® slightly improves diagnostic sensitivity while maintaining a statistically equivalent specificity. Diagnosis was reached 1.6 times faster with CytoProcessor® compared to using a microscope.
Conclusion
CytoProcessor® is a robust automated cervical cytology screening system that can be used successfully with samples having very different characteristics. As previously shown, CytoProcessor® confers significant gains in processing time and diagnostic precision. CytoProcessor® is accessible through a secured internet connection, making remote diagnosis of Papanicolaou tests possible.
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