CytoProcessor® - Annette's Case n°12

CytoProcessor AI for Digital Cytology supports in case of pitfalls in Cervical Cytology Screening:

as example HSIL – Endocervical Glandular Involvement (EGI)

As a Cytotechnologist or Cyto-Pathologist you must have optimal sample collections, in the screening for Cervical Cancer, for making accurate diagnoses.
The samples should include cells from both the transformation zone and the endocervical glandular invaginations.
Having an accurate reliable diagnosis is important as it influence on the clinical treatment plan, especially in cases of HSIL – EGI.

CytoProcessor aids the screener by showing on the first page of the abnormal gallery appropriate to the diagnosis of HSIL-EGI they commonly present:

Grape bunch shaped look-alikes syncytial-like cell crowded groups of squamous cells with high NCR, anisonucleose, coarse chromatin pattern, even mimicking glandular differentiation as rosette-like structures and micro-acini can be seen.

Naked atypical nuclei - who are often present

Isolated HSIL cells showing the basics of the cytological criteria for HSIL lesions: high N:C ratio, uneven distributed coarse chromatin pattern, dense cytoplasm, and irregular membrane.

Suboptimal performed samples, containing just a few abnormal cells, can lead to miss diagnosing.

Note: HSIL-EGC lacks the specific features for AIS, such as feathering and pseudostratification.
Fact: HSIL and AGC/AIS could be present in the same case.

— Annette W. Hamminga (CTIAC), Digital Cytology Expert at Datexim

Read the article: Journal of Pathology and Translational Medicine

CytoProcessor® is a CE marked IVD device, intended for use by healthcare professionals only. Please consult the user guide provided by the manufacturer, DATEXIM, for detailed conditions of use and recommendations for safe and effective operation.