News

CytoProcessor® - Annette's Case n°15

OCTOBER 1 2024

Detection of Microorganism in the battle against Cervical Cancer with Datexim’s CytoProcessor®.

Did you know ?
That the naturally occurring Lactobacillus plays an important role in protecting the vaginal epithelium in a healthy vagina.

During sexual maturity, a shift in the vaginal flora may occur, disrupting the microbiological balance and resulting in an increase in pH, allowing HPV viruses to gain easier access to the basal cells.

Therefor it’s importance to detect not only abnormal cells - as a result of an HPV infection - in the screening for Cervical Cancer but also the presence of Bacterial Vaginosis, Mycosis, Actinomyces or Trichomonas Vaginalis in a PAP smear.

The presence of these pathogens may result in an increasing risk of reduced clearance of a persistent HPV infection.

¹ Bacterial Vaginosis Linked With Persistent HPV Infections

² Role of Lactobacillus in cervical cancer

Dozens (>30) of sexual transmitted Infections are known.

The most common STI’s seen in a PAP smear are:

HPV

Bacterial Vaginosis - is a collective name for various bacteria

Candida albicans

Trichomonas Vaginalis

Actinomyces

Will early detection and therefor timely treatment of these pathological microorganisms lead to a reduction in the number of abnormal PAP smears? (more precisely detection of the microorganisms must be done by microbiology for confirmation and optimal treatment of the detected pathogen)

³ Sexually transmitted infections (STIs) (who.int)

Datexim has developed algorithms on CytoProcessor® to detect these microorganisms to aid you as CytoTechnologist and Cyto-Pathologist to find both abnormal cells and microorganism.

These features are illustrated here as part of a recent CytoProcessor® software update.
Learn more here: CytoProcessor 3.3

— Annette W. Hamminga (CTIAC), Digital Cytology Expert at Datexim

CytoProcessor® is a CE marked IVD device, intended for use by healthcare professionals only. Please consult the user guide provided by the manufacturer, DATEXIM, for detailed conditions of use and recommendations for safe and effective operation.

PICTURE 1
HSIL + Trichomonas Vaginalis (ThinPrep | 3DHistech P1000)